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讲师

刘啸尘

博士、讲师、硕士生导师

个人信息:

1.基本信息

刘啸尘,韦德官方网站讲师,博士,中国化工学会专业会员,《韦德官方网站学报》青年编委。主持国家自然基金青年基金1项,陕西省重点研发计划1项,陕西省自然科学基础研究计划1项;联合主持国家自然科学基金地区项目2项;参与国家级研究课题2项(国家重点研发计划1项,国家自然科学基金面上项目1项),省部级课题2项,厅局级课题3项。在Chem Eng JBioresource TechnolJ Environ Manage等SCI收录期刊发表论文近20篇。参编中文教材2部,申请发明专利7项;获省部级科学技术奖和荣誉2项。指导究生参加研究生创新基金1项,指导研究生参加科学实验展演大赛,并获得陕西省优秀奖。指导研究生发表论文获得指导研究生发表论文获得韦德官方网站研究生创新成果奖一等奖。指导研究生参加第八届“互联网+”老员工创新创业大赛,并获得校级金奖和陕西赛区省级铜奖。指导研究生参加韦德官方网站第十四届“希望杯”老员工创业计划竞赛,并获得银奖。

现主要从事微生物与植物互作机制研究、微生物材料开发及其功能强化研究、高附加值化合物生物转化研究。首先,针对陕北干旱半干旱地区土壤盐碱化严重、化肥超量低效、环境污染严重以及农业废弃物难处理等问题,开展了缓解土壤盐渍化根际微生物及生物质资源利用研究,研究了植物根际促生菌(PGPR)对植物防病促生性能及作用机制、开发了微波催化热解制备生物炭技术及生物炭基解盐缓释菌剂材料产品、开发了农业废弃食用菌渣资源化利用成产生物有机肥技术。其次,针对高活性天然产物在自然界中含量稀少来源受限,且结构复杂难以大量合成的问题,从生物大数据及多组学两个方面开展关键酶的挖掘,并对关键酶进行功能验证,实现了酶法合成高附加值天然产物。为了克服游离酶生物催化转化高附加值天然产物的缺陷,开展了MOFs和磁性纳米粒子等新型固定化载体对游离酶进行固定化研究,建立了酶固定化工艺技术,解析固定化酶的蛋白分布、形态结构、催化活性及协同催化机理。

2.招生专业及研究方向

化学工程与技术专业,研究方向为生物化工

材料与化工专业,研究方向为生物化工

3.开设课程

基因工程、发酵工程、生物工程工厂设计

4.主要研究成果

4.1主持科研项目

1.国家自然科学基金(青年),22008186,恶臭假单胞菌的ACC脱氨酶模块构建及其解盐促生功能强化,2021.01-2023.1224万元,主持。

2.国家自然科学基金(地区),32060026,盐胁迫下根际促生菌与辣椒根系互作及抗盐机制研究,2021.01-2024.1212万元/34万元,主持。

3.国家自然科学基金(地区),22286045,生物炭基保水缓释菌剂的制备及其抗旱促生机理研究,2023.01-2026.1216.5万元/33万元,主持。

4.陕西省科技厅重点研发计划,2022NY-056,食用菌渣生物炭基菌剂制备技术及其应用研究,2022-01-2023-128万元,主持。

5.陕西省科技厅自然科学基金,2019JQ-523,人参皂苷Ro生物合成途径中糖基转移酶基因的挖掘和功能分析,2019-01-2020-123万元,主持。

6.国家重点研发计划,2021YFC2101501,天然产物酶法合成催化机制解析与关键技术,2021.07-2024.0615万元/472万元,项目骨干。

7.石河子大学双一流重点科技项目,SHYL-ZD201805,根际促生菌群与棉花互作及抗盐胁迫分子基础,2018-01-2020-1210万元,子课题主持。

8.韦德官方网站校博士科研启动项目,107020361,人参皂苷类衍生物人工合成体系的构建与优化,2018-12-2021-1210万元,主持。

4.2近年发表代表性论文

1. Xueping Li,Zhansheng Wu*, Xiyang Tao, Runze Li, Duoduo Tian,Xiaochen Liu*, Gentle one-step co-precipitation to synthesize bimetallic CoCu-MOF immobilized laccase for boosting enzyme stability and Congo red removal,Journal of Hazardous Materials. 2022, 438,129525(中科院一区,IF=14.224, Top期刊).

2. Changhao Liu,Xiaocheng Liu*, Yanhui He, Xiongfang An, Daidi Fan,Zhansheng Wu*, Microwave- assisted catalytic pyrolysis of apple wood to produce biochar: Co-pyrolysis behavior, pyrolysis kinetics analysis and evaluation of microbial carriers,Bioresource Technology,2021, 320,124345: 1-9(中科院一区,IF=11.889, Top期刊).

3. Zhidong Tao,Xiaochen Liu*, Linlin Sun,Effects of two types nitrogen sources on humification processes and phosphorus dynamics during the aerobic composting of spent mushroom substrate,Journal of Environmental Management, 2022,317: 115453-115453. (中科院二区,IF=8.7, Top期刊)

4. Duoduo Tian, Runze Li,Xiaochen Liu, Zhuo Tu, Daidi Fan, Zhansheng Wu*, Synthesis of L-aspartic acid-based bimetallic hybrid nanoflowers to immobilization snailase for production of rare ginsenoside Compound K, Journal of Materials Chemistry B, 2023,(IF=7.571,中科院二区).

5. Runze Li, Xueping Li, Duoduo Tian,Xiaochen Liu,Zhansheng Wu*, Amino-functionalized MOF immobilized laccase for enhancing enzyme activity stability and degrading Congo red, Journal of the Taiwan Institute of Chemical Engineers, 2023, 143, 104647 (IF=5.477,中科院二区).

6. Runze Li,Xiaochen Liu, Xueping Li, Duoduo Tian, Zhansheng Wu*, Co-immobilized β-glucosidase and snailase in green synthesized Zn-BTC for ginsenoside CK biocatalysis, Biochemical Engineering Journal,2022, 188, 108677(IF=4.446,中科院三区).

7. Fan Yang, Zhansheng Wu*, Zhidong Tao, Daidi Fan,Xiaochen Liu*, Simultaneous transformation of ginsenoside Rb1 into rare ginsenoside F2 and Compound K by the extracellular enzyme from Aspergillus Niger Wu-16. Bioresource Technology reports, 2023. DOI:10.1016/J.BITEB.2023.101419.

8. Hongyang Long, Xueping Li, Xiaochen Liu*, Wanying Wang, Xia Yang, Zhansheng Wu*. Immobilization of Laccase by Alkali-Etched Bimetallic CoCu-MOF To Enhance Enzyme Loading and Congo Red Degradation, Langmuir, 2023,39,8404-8413(IF=3.9,中科院二区)

9. Mengmeng Wei,Xiaochen Liu*, Yanhui He, Xiaolin Xu, Zhansheng Wu*, Kun Yu, Xu Zheng. Biochar inoculated with Pseudomonas putida improves grape (Vitis vinifera L.) fruit quality and alters bacterial diversity, Rhizosphere, 2020, 16:100261.

10.Xiongfang An, Zhansheng Wu* ,Junzhi Yu, Giancarlo Cravotto,Xiaochen Liu, Qing Li, Bing Yu*.Copyrolysis of Biomass, Bentonite, and Nutrients as a New Strategy for the Synthesis of Improved Biochar-Based Slow-Release Fertilizers. ACS Sustainable Chemistry & Engineering, 2020, 8(8): 3181-3190.

11.Zhansheng Wu*, Yuanyuan Huang, Yan Li, Jiawei Dong,Xiaochen Liu*, Chun Li, Bio-control of Rhizoctonia solani via induction of the defense mechanism and antimicrobial compounds produced by Bacillus subtilis SL-44 on pepper (Capsicum annuum L.). Frontiers in Microbiology, 2019, 10: 2676.

12.Zhansheng Wu*, Xiaoqing Chen,Xiaochen Liu, Xia Yang, Yan Yang, A Ternary Magnetic Recyclable ZnO/Fe3O4/g-C3N4 Composite Photocatalyst for Efficient Photodegradation of Monoazo Dye, Nanoscale Research Letters, 2019,14(147):1-14.

13.Siyuan Tao, Zhansheng Wu*, Mengmeng Wei,Xiaochen Liu, Yanhui He, Bang-Ce Ye, Bacillus subtilis SL-13 biochar formulation promotes pepper growth and soil improvement, Canadian Journal of Microbiology, 2019, 65(5): 333-342.

14.Yanhui He, Zhansheng Wu*, Wenfei Wang, Bang-Ce Ye, Furong Zhang,Xiaochen Liu, Different responses of Capsicum annuum L. root and shoot to salt stress with Pseudomonas putida Rs-198 inoculation, Journal of Plant Growth Regulation, 2019, 38(3): 799-811.

15.Yanhui He, Zhansheng Wu*, Wenfei Wang,Xiaochen Liu, Bang-Ce Ye, Bacteria community and phosphorus species in pepper Rhizosphere soils mediated by Pseudomonas putida Rs-198 inoculation, Rhizosphere, 2019, 38(3):799-811.

16.Xiaochen Liu,Liang Zhang,Xudong Feng, Bo Lv*,Chun Li.Biosynthesis of Glycyrrhetinic Acid-3‑O‑monoglucose Using Glycosyltransferase UGT73C11 from Barbarea vulgaris.Industrial & Engineering Chemistry Research, 2017, 56(51): 14949 -14958.

17.Xiaoxia Li#,Xiaochen Liu#, Shihan Wu, Aamir Rasool, Jiane Zuo, Chun Li*, Guiyan Liu*. Microbial diversity and community distribution in different functional zones of continuous aerobic–anaerobic coupled process for sludge in situ reduction[J]. Chemical Engineering Journal, 2014, 257:74-81.

18.孙琳琳,刘啸尘*,张宇飞,武占省,岳俊松.酿酒酵母启动子的克隆及特性表征[J].韦德官方网站学报,2023,37(03):51-58.DOI:10.13338/j.issn.1674-649x.2023.03.008.

19.刘啸尘,范代娣,杨帆,武占省*.人参皂苷化合物生物合成进展[J].生物工程杂志, 2021,41(1): 80-93.

20.刘啸尘,刘护,张良,李春*.细胞生物过程中的糖基化反应及其功能[J].生物工程杂志, 2018,38(1): 69-77.

21.张良,刘啸尘,刘桂艳,吕波,冯旭东,李春*.生物转化过程中的能量驱动与再生[J].化工学报, 2018, 69(7):2807-2814.


4.3发明专利

1.刘啸尘,孙琳琳,武占省,何艳慧,田飞,周小虎,贾欣玉.一种解盐促生复合微生物菌剂制备方法及其应用.申请号或专利号:CN 202310706376.3

2.李春,刘啸尘,张良,倪江平,刘护.一种酶法合成3-O-葡萄糖基甘草次酸的方法.申请号或专利号:CN 201710950480.1

3.李春,赵雨佳,刘啸尘,蔚欢,樊婧婧.一种利用酿酒酵母合成3-O-葡萄糖基齐墩果酸和纤维二糖齐墩果酸的方法.申请号或专利号:CN 201610851950.4.

4.李春,赵雨佳,冯旭东,朱明,刘啸尘,樊婧婧,王晨,周晓宏.一种糖基转移酶在合成甘草酸中的应用。申请号或专利号:CN 201811310750.3

5.联系方式:

邮箱:bitericliu@163.com;liuxiaochen@xpu.edu.cn;电话/微信:13718472234